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The top seed in the NFC will be up for grabs when the Seattle Seahawks battle the San Francisco 49ers in a key NFC West matchup on Saturday night. Seattle is coming off a 28-10 win at Carolina on Sunday, while San Francisco outlasted Chicago 42-38. The Seahawks (13-3), who lead the NFC West, have won six in a row. The 49ers (12-4), who are second in the division, have also won six straight and are 9-2 within the conference. Receiver Ricky Pearsall (knee, ankle), tight end George Kittle (ankle) and offensive tackle Trent Williams (hamstring) are all questionable for the Niners. Starting offensive lineman Charles Cross (hamstring) is out for Seattle. 

Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8 p.m. ET. Seattle is the 2.5-point favorite in the latest 49ers vs. Seahawks odds, while the over/under for total points scored is 47.5 via DraftKings Sportsbook, down two points from the opening line. Before making any Seahawks vs. 49ers picks, check out the NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Seahawks vs. 49ers. You can visit SportsLine now to see the picks. Here are the NFL odds and trends for 49ers vs. Seahawks:

Seahawks vs. 49ers spread

Seattle -2.5 at DraftKings Sportsbook

Seahawks vs. 49ers over/under

47.5 points

Seahawks vs. 49ers money line 

Seattle -144, San Francisco +121

Seahawks vs. 49ers picks

See picks at SportsLine

Seahawks vs. 49ers streaming 

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Why the Seahawks can cover

Veteran quarterback Sam Darnold helps power the Seattle offense. He has completed 67.2% of his passes for 3,850 yards and 25 touchdowns with 14 interceptions and a 99.2 rating. In a 38-37 overtime win over the Los Angeles Rams on Dec. 18, he completed 22 of 34 passes for 270 yards and two touchdowns with two interceptions. In a 38-14 win at Washington on Nov. 2, he completed 21 of 24 passes for 330 yards and four touchdowns with one pick.

His top target is third-year veteran wide receiver Jaxon Smith-Njigba. In 16 games, he has 113 receptions for 1,709 yards and 10 touchdowns. He has 27 explosive plays of 20 yards or more, including a long of 63, with 505 yards after the catch and 74 first-down conversions. In the win over Carolina, he caught nine passes for 72 yards, including a long of 18. See which team to back at SportsLine. 

Why the 49ers can cover

Quarterback Brock Purdy has been solid since returning from injury. In eight games this season, he has completed 69.3% of his passes for 2,040 yards and 20 touchdowns with nine interceptions and a 104.2 rating. He has also carried 31 times for 126 yards and three touchdowns. In the win over Chicago, he completed 24 of 33 passes for 303 yards and three touchdowns with one interception. He also rushed six times for 28 yards and two touchdowns.

San Francisco's MVP may be Christian McCaffrey, who does not have an injury designation for the game despite missing practice on Tuesday (back). In 16 games this season, he has carried 303 times for 1,179 yards (3.9 average) and 10 touchdowns. He also leads the 49ers in receiving, with 96 receptions for 890 yards and seven touchdowns. In the win over the Bears, he carried 23 times for 140 yards (6.1 average) and one touchdown, while catching four passes for 41 yards. See which team to back at SportsLine.

How to make Seahawks vs. 49ers picks

SportsLine's model is going Over on the total, projecting 51 combined points. It also says one side of the spread hits in more than 50% of simulations. You can only get the pick at SportsLine. 

So who wins 49ers vs. Seahawks, and which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the Seahawks vs. 49ers spread to jump on, all from the advanced model that finished up over $7,000 on its NFL picks since its inception, and find out.